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  • Ѽ   Assistant Professor
  • Organic Chemistry
  • Ph.D. 2012, Massachusetts Institute of Technology

Contact information

Tel: (office) +82-42-350-2818, (lab) +82-42-350-2858
Location: (office) Room 4102 (Bldg. E6-4), (lab) Room 4119, 4120 (Bldg. E6-4)
Fax: +82-42-350-2810

Education

Ph.D.: Organic Chemistry, Massachusetts Institute of Technology June, 2012 (Advisor: Professor Mohammad Movassaghi).
B.S.: Chemistry, KAIST (Korea Advanced Institute of Science and Technology) February, 2006 summa cum laude (2nd out of 412)

Career

Assistant Professor: Department of Chemistry, KAIST, 2014 –
Postdoctoral Associate: Department of Chemistry, Yale University, 2012 – 2014 (Advisor: Scott J. Miller)

Awards

Kenneth M. Gordon Summer Graduate Fellowship in Organic Chemistry (2011)
EMD Serono Summer Graduate Fellowship (2010)
The Korea Foundation for Advanced Studies Scholarship (2006 – 2011)
GE Foundation Scholar-Leaders Scholarship (2002, 2005)
Gold Prize in the 6th Samsung Humantech Thesis Prize (2000)

RESEARCH AREA


Brief Introduction

 

The field of total synthesis of natural products has shown dramatic progress over the last century. Through the collective effort of the synthetic community, complex targets have been synthesized using inventive solutions, and those solutions have formed the basis for the development of new drugs and materials. With increasing expectations imposed on synthetic organic chemists, the role of total synthesis (i) as a driving force for the discovery of novel and efficient reactions, (ii) as a tool to enhance the understanding of biosynthetic machineries, and (iii) as a means for generating chemicals of extraordinary biological significance in substantial quantities will continue to grow.

With these goals in mind, our group is interested in the synthesis of complex natural products. Our targets would serve as an arena for the exploration of intrinsic reactivities of the molecules and the discovery of new transformations for a novel type of bond formation. Our pursuit of convergent and flexible synthetic approaches should enable access to not only a single target but various natural products with structural and biosynthetic relevance, or unnatural products with higher biological potency.

Research topics

Natural products total synthesis
Methods development for novel type of bond formation
Development of chemical tools for biological studies

Representative publications

• Han, S.; Le, B. V.; Hajare, H. S.; Baxter, R. G. H.; Miller, S. J. X-ray Crystal Structure of Teicoplanin A2-2 Bound to a Catalytic Peptide Sequence via the Carrier Protein Strategy. Submitted.
• Han, S.; Morrison, K.; Hergenrother, P. J.; Movassaghi, M. Total Synthesis, Stereochemical Assignment, and Biological Activity of All Known (–)-Trigonoliimines. J. Org. Chem. 2014, 79, 473 (Featured Article, front cover).
• Han, S.; Siegel, D. S.; Morrison, K. C.; Hergenrother, P. J.; Movassaghi, M. Synthesis and Anticancer Activity of all Known (–)-Agelastatin Alkaloids. J. Org. Chem. 2013, 78, 11970.
• Han, S.; Miller, S. J. Asymmetric Catalysis at a Distance: Catalytic, Site-Selective Phosphorylation of Teicoplanin. J. Am. Chem. Soc. 2013, 135, 12414.
• Han, S.; Siegel, D. S.; Movassaghi, M. Lithiation and Electrophilic Substitution of Dimethyl Triazones. Tetrahedron Lett. 2012, 53, 3722.
• Han, S.; Movassaghi, M. Concise Total Synthesis and Stereochemical Revision of all (–)-Trigonoliimines. J. Am. Chem. Soc. 2011, 133, 10768 (Most Read Paper on July, 2011 in the J. Am. Chem. Soc).
• Movassaghi, M.; Siegel, S. D.; Han, S. Total Synthesis of all (–)-Agelastatin Alkaloids. Chem. Sci. 2010, 1, 561 (Front cover).
• Oh, S.; Park, J.; Han, S.; Lee, J.; Roh, E.; Lee, C. J. Development of Selective Blockers for Ca2+-Activated Cl- Channel Using Xenopus laevis oocytes with an Improved Drug Screening Strategy. Molecular Brain, 2008, 1, 14.
• Chang, S.; Lee, M.; Jung, D.; Yoo, E.; Cho, S.; Han, S. Catalytic One-pot Synthesis of Cyclic Amidine by Virtue of Tandem Reactions Involving Intramolecular Hydroamination Under Mild Condition. J. Am. Chem. Soc. 2006, 128, 12366.