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Ѽ , ߵġ ׾ ĺ ռ 2018-11-15



ȭа Ѽ ߵ ġ, ׾ ĺ ִ õ ΰ ռϴ ߴ. ߿ ִ īŸƾ(catharanthine) ȭ 7 ̺ Ʈ̺ õ ռس´. ̹ ߵ ġ, ׾ ĺ õ ȴ.

 

ñ, ڻհ 1 ڷ ȭ о м (Cell) ڸ (Chem) 11 15 ڿ ƴ. ( : Biosynthetically Inspired Transformation of Iboga to Monomeric Post-Iboga Alkaloids, ռ ̺ Į̵ ü Ʈ̺ Į̵ ȯ

̺ Į̵尡 а ̵ õ ߵ ġν ɼ ̴. ̺ Į̵尡 ռ õ ƾ(vinblastine) ׾ ̰ ִ. ֱٿ ̺ Į̵κ ڿ Ļ پ õ ߰ߵǸ а ɵ Ŀ ִ. õ ռ() ۹κ ٴܰ ȭй ϴ õ ռϴ й о̴. ׷ ٴܰ ȭй ġ ռȿ Ѱ谡 ִ. ̺ Į̵ õ īŸƾ ǰǾ౹(FDA) ׾ (Navelbine) ߿ ִٴ ߴ. ȭ īŸƾ ΰġ Ʈ̺ õ ȿ ռߴ. ̹ ̺ Į̵忡 ڿ ĻǸ鼭 ̷ õ Ʈ̺ Į̵ ̸ . ׸ پ ȿ ۿ Ĺ ̷ ̺ ȭ ϴ ߴ. ռ Ʈ̺ Į̵ Ÿƾ(tabertinggine), ƾ(voatinggine), Ǵ(dippinine) B ƾ Ǵ B ռ̴. Ư Ǵ õ 30 ̻ а ޾ƿ Ҷ õ µ ̹ ʷ ռ ߴ.

 

̹ Ʈ̺ Į̵ ռ ο з ο ̴ پ ׾ ߵ ġ ĺ ռ ִ õ Ȯߴٴ ǰ ִ ߴ. ̹ ѱ ̰о ʿ ߰߿ ƴ.

 

 

׸

׸1. Ʈ̺ Į̵ ռ ĵ



׸2. Ǵ B ռ