Contact information
Tel: (office) +82-42-350-2835, (lab) +82-42-350-####
Location: (office) Room 606 (E6-6), (lab) Room ###
Fax: +82-42-350-2810
Education
PhD, POSTECH, 2018
BS, POSTECH, 2013
Professional Experiences
KAIST, Assistant Professor, 2023
Stanford University, Postdoctoral Scholar, 2019–2023
POSTECH, Postdoctoral Scholar, 2018-2019
Tohoku University, Exchange Student, 2014
Awards
• Plant-Based Diet Initiative (PBDI), Beyond Meat®, Seed Grant Award 2022
• Presentation Excellence Award, Korean Chemical Society (KCS) 2017
• Three-Minutes Scientific Speech Competitions, POSTECH 2016
• Bronze Medalist, Chemistry Competitions, POSTECH 2006
• Silver Medalist, Korean Chemistry Olympiad (KCHO) 2006
• Bronze Medalist, Korean Chemistry Olympiad (KCHO) 2005
RESEARCH AREA
Brief Introduction
Research topics
• Understanding of DNA damage and repair systems
• Visualizing the dynamics of base excision repair in mitochondrial DNA
• Biochemical tools enhancing the efficacy of mRNA therapeutics.
• Methodology of in vitro modulation of DNA/RNA using DNA repair enzymes
Representative publications
1. Y. W. Jun, M. Kant, E. Coskun, P. Jaruga, M. Dizdaroglu, and E. T. Kool* “Genetic Risks from Heat-Damaged DNA in Food” ACS Cent. Sci. 2023, accepted
2. Y. W. Jun, and E. T. Kool* “Chemical Tools for the Study of DNA Repair” Acc. Chem. Res. 2022, 55, 3495
3. Y. W. Jun, E. M. Harcourt, L. Xiao, D. L. Wilson, and E. T. Kool* “Efficient DNA Fluorescence Labeling vis Base Excision Trapping” Nat. Commun. 2022, 13, 5043.
4. Y. W. Jun, E. Albarran, D. L. Wilson, J. Ding, and E. T. Kool* “Fluorescence Imaging of Mitochondrial DNA Base Excision Repair Reveals Dynamics of Oxidative Stress Responses” Angew. Chem. Int. Ed. 2022, 61, e202111829.
5. Y. W. Jun, D. L. Wilson, A. M. Kietrys, E. R. Lotsof, S. G. Colon, S. S. David, and E. T. Kool* “An Excimer Clamp for Measuring Damaged Base Excision by the DNA Repair Enzyme NTH1” Angew. Chem. Int. Ed. 2020, 132, 7520.
6. Y. W. Jun, T. Wang, S. Hwang, D. Kim, D. Ma, K. H. Kim, S. Kim, J. Jung, and K. H. Ahn* “A Ratiometric Two-Photon Fluorescent Probe for Tracking the Lysosomal ATP: Direct in Cellulo Observation of Lysosomal Membrane Fusion Processes” Angew. Chem. Int. Ed. 2018, 57, 10142.
7. Y. W. Jun, H. R. Kim, Y. J. Reo, M. Dai, and K. H. Ahn* “Addressing the Auto-Fluorescence Issue in Deep Tissue Imaging by Two-Photon Microscopy: Significance of Far-Red Emitting Dyes” Chem. Sci. 2017, 8, 7696.
