Contact information
Tel: (office) +82-42-350-2846, (lab) +82-42-350-2886
Location: (office) Room 4106 (Bldg. E6-4), (lab) Room 4114, 4116 (Bldg. E6-4)
Fax: +82-42-350-2810
E-mail: hee-seung_lee@kaist.ac.kr
Website: http://hslee.kaist.ac.kr
Education
Ph.D. Department of Chemistry, KAIST (1996)
M.S. Department of Chemistry, KAIST (1992)
B.S. Department of Chemistry (Cum Laude), KAIST (1990)
Career
Assistant & Associate Professor, 2004-present, Department of Chemistry, KAIST
Postdoc Associate, 1999-2003, Department of Chemistry, Univ. of Wisconsin, Madison
Senior Scientist, 1996-1999, Samsung Fine Chemicals R&D Center
Academes and Society
Korean chemical society
Awards
2011 범부처 국가연구개발사업 우수성과 100선 선정 (국가과학기술위원회)
2011 Sehi Jang Excellent Research Award (Organic Chem. Division, Korean Chemical Society)
2011 Asian Core Program (ACP) Lectureship Award (Thailand)
2010 Best Lecturer Award (College of Natural Science, KAIST)
2010 The 4th KRIBB Poster Festival Innovation Award (KRIBB)
2010 Asian Core Program (ACP) Lectureship Award (Taiwan)
2008 Asian Core Program (ACP) Lectureship Award (Japan)
2008 Best Lecturer Award (Department of Chemistry, KAIST)
2007 Best Lecturer Award (College of Natural Science, KAIST)
2005 Synlett Journal Award (Thieme)
RESEARCH AREA
Brief Introduction
Main research in our group is to create new foldamers (unnatural oligomers) that can mimic structures and functions of biopolymers such as peptides and nucleic acids. Foldamer research is motivated by many different goals ranging from and emerging diseases to the design of new materials for use in bionanotechnology.
Research topics
* Foldamers and Foldectures (Self-Assembled 3D Molecular Architectures)
* Asymmetric Organic Synthesis, Antibiotics and Anticancer Drugs
* Molecular Recognition, Noncovalent Interactions, PNA, Biomineralization
Representative publications
1. Kim, J.(co-first author); Kwon, S.(co-first author); Kim, S. H.; Lee, C.-K.; Lee, J.-H.; Cho, S. J.; Lee, H.-S; Ihee, H., “Microtubes with Rectangular Cross-Section by the Self-Assembly of a short b-Peptide Foldamer”, J. Am. Chem. Soc. 2012, 134, 20573.
2. Kwon, S.; Shin, H. S.; Gong, J.; Eom, J. H.; Jeon, A.; Yoo, S. H.; Chung, I. S.; Cho, S. J.; Lee, H.-S., “Self-Assembled Peptide Architecture with a Tooth Shape: Folding into Shape” J. Am. Chem. Soc. 2011, 133, 17618.
3. Medda, A. K.; Park, C. M.; Jeon, A.; Kim, H.; Sohn, J.-H.; Lee, H.-S., “A Nonpeptidic Reverse-Turn Scaffold Stabilized by Urea-Based Dual Intramolecular Hydrogen Bonding” Org. Lett. 2011, 13, 3486.
4. Seo, Y.-J.; Lim, J.; Lee, E.-H.; Ok, T.; Yoon, J.; Lee, J.-H.; Lee, H.-S., “Base-pair Opening Kinetics Study of the aegPNA:DNA Hydrid Duplex Containing a Site-specific GNA-like Chiral PNA Monomer” Nuc. Acids Res. 2011, 39, 7329.
5. Kwon, S.; Jeon, A.; Yoo, S. H.; Chung, I. S.; Lee, H.-S., “Unprecedented Molecular Architectures by the Controlled Self-Assembly of a b-Peptide Foldamer” Angew. Chem. Int. Ed. 2010, 49, 8232.
6. Han, T. H.; Ok, T.; Kim, J.; Shin, D. O.; Ihee, H.; Lee, H.-S.; Kim, S. O., “Bionanosphere Lithography via Hierarchical Peptide Self-Assembly of Triphenylalanine” Small. 2010, 6, 945.
