Contact information
Tel: (office) +82-42-350-2817, (lab) +82-42-350-2857
Location: (office) Room 507 (Bldg. E6-6), (lab) Room 515 (Bldg. E6-6)
Fax: +82-42-350-2810
Education
Ph.D. Chemistry (in Biological Chemistry), MIT (2005.09)
M.S. Chemistry (in Biochemistry), KAIST (2000.02)
B.S. Chemistry, KAIST (1998.02)
Career
Senior research scientist, 2005-2012, KRIBB, Daejon, Korea
Assistant professor, 2008-2012, UST, Daejon, Korea
RESEARCH AREA
Brief Introduction
Tools to follow biomolecules (proteins, DNA/RNAs, lipids, etc …) have greatly increased our understanding on how the nature precisely controls biological processes. Researchers want to locate, quantitate, and also control the target biomolecule under hopefully any circumstances; in tubes, inside cells, or only in cancer cells. In addition, the target molecules are generally with many other molecules around (such as in the cellular context), requiring specific probes which can help us to follow only those targets. The main purpose of our research is to create our own biochemical probes, and apply them for the development of new bioanalytical tools, by which offering unprecedented and distinct ways to study life science. Primary biomolecule targets are several aberrant forms of nature that are highly important for cellular regulation and disease occurrence; while their bioanalysis has been restricted by lack of proper analytical handles.
Research topics
- Biochemical probe development
- biosensors
- in cell biomolecular analysis
- nano-bio interfacing
Representative publications
- “Two-temperature hybridization for microarray detection of label-free microRNAs with attomole detection and superior specificity”, Angew. Chem. Int. ed., 2011, 50, 12487
- “Splitting and self-assembling of far-red fluorescent protein with an engineered beta strand peptide: Application for alpha-synuclein imaging in mammalian cells”, Biomaterials, 2011, 32, 9051
- “Fabrication of a Structure-Specific RNA Binder for Array Detection of Label-Free MicroRNA”, Angew. Chem. Int. ed., 2010, 49, 8662
- “Photoactivable Antibody Binding Protein: Site-Selective and Covalent Coupling of Antibody”, Anal. Chem., 2009, 81, 936
- “Direct Cellular Responses to Platinum-Induced DNA Damage”, Chem. Rev., 2007, 107, 1387
